Press Release / Health and Fitness / REST serves as a reliable predictor of Alzheimer’s disease and other aging-related dementias

REST serves as a reliable predictor of Alzheimer’s disease and other aging-related dementias

Alzheimer’s disease (AD) is undoubtedly one of the biggest scientific mysteries of the medical world. What is a reliable indicator of this disease? Why do some people who accumulate the plaques so strongly associated with AD, never develop the disease? In a recent Nature paper, a group of Harvard scientists identified REST, a neuro-protective protein which is lost in AD, but induced by Wnt signaling in normal aging brain to repress genes associated with cell death and AD, indicating that REST can be a reliable predictor of neurodegenerative diseases, like AD.



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